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Figure 2. Three different scenarios of radiation and implant-based reconstruction. (A and B) A 45-year-old female patient with right breast cancer staged T2N1aM0, who underwent skin-sparing mastectomy and immediate direct-to-implant breast reconstruction without postmastectomy radiotherapy. (A) Preoperative view. The patient was satisfied with the postoperative symmetric result at the follow-up time of 66 months. (B) Post-OP 66-month AP view; (C and D) A 39-year-old female patient with left breast cancer staged T1cN2a, who received skin-sparing mastectomy and immediate implant-based breast reconstruction as direct-to-implant breast reconstruction. PMRT was delivered to her whole left breast because of the advanced cancer stage. (C) Preoperative anterior view of the breasts. (D) Post-OP 8-month and post-PMRT one-month AP view; (E and F) A 55-year-old female patient with a history of left breast cancer post breast conservation surgery and postoperative whole breast radiation developed tumor recurrence five years after the first surgery. She later underwent NSM and immediate breast reconstruction in the form of direct-to-implant. (E) Preoperative view before the NSM. (F) Post-OP 4-month AP view. PMRT: Postmastectomy radiation therapy; NSM: nipple-sparing mastectomy.