REFERENCES
1. Yuan, Y.; Li, M.; Harrison, W.; Zhang, Z.; Zhao, H. Harnessing photoenzymatic reactions for unnatural biosynthesis in microorganisms. Nat. Catal. 2026, 9, 62-72.
2. Yang, Y.; Arnold, F. H. Navigating the unnatural reaction space: directed evolution of heme proteins for selective carbene and nitrene transfer. Acc. Chem. Res. 2021, 54, 1209-25.
3. Kissman, E. N.; Sosa, M. B.; Millar, D. C.; Koleski, E. J.; Thevasundaram, K.; Chang, M. C. Y. Expanding chemistry through in vitro and in vivo biocatalysis. Nature 2024, 631, 37-48.
4. Brouwer, B.; Della-Felice, F.; Illies, J. H.; Iglesias-Moncayo, E.; Roelfes, G.; Drienovská, I. Noncanonical amino acids: bringing new-to-nature functionalities to biocatalysis. Chem. Rev. 2024, 124, 10877-923.
5. Emmanuel, M. A.; Bender, S. G.; Bilodeau, C.; et al. Photobiocatalytic strategies for organic synthesis. Chem. Rev. 2023, 123, 5459-520.
6. Yu, J.; Chen, B.; Huang, X. Single-electron oxidation triggered by visible-light-excited enzymes for asymmetric biocatalysis. Angew. Chem. Int. Ed. Engl. 2025, 64, e202419262.
7. Peng, Y.; Chen, Z.; Xu, J.; Wu, Q. Recent advances in photobiocatalysis for selective organic synthesis. Org. Process. Res. Dev. 2022, 26, 1900-13.
8. Huang, J.; Liu, Z.; Bloomer, B. J.; et al. Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme. Nat. Chem. 2021, 13, 1186-91.
9. Huang, J.; Quest, A.; Cruz-Morales, P.; et al. Complete integration of carbene-transfer chemistry into biosynthesis. Nature 2023, 617, 403-8.





