fig2

Figure 2. Impact of lipid metabolic reprogramming on the immune response in HCC. Sharp arrows denote positive regulation, whereas blunt arrows denote negative regulation. Upward symbols represent upregulation, whereas downward symbols represent downregulation. Major actionable targets are indicated by distinct geometric symbols: triangles represent metabolic enzymes, circles represent transporters, and squares represent transcription factors. ACC: Acetyl-CoA carboxylase; ACLY: ATP citrate lyase; CD36: cluster of differentiation 36; CPT1A: carnitine palmitoyltransferase 1A; FASN: fatty acid synthase; FATP4: fatty acid transport protein 4; HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase; PPARβ/δ: peroxisome proliferator-activated receptor β/δ; PPARγ: peroxisome proliferator-activated receptor γ; SOAT1: sterol O-acyltransferase 1; STAT3: signal transducer and activator of transcription 3.