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Figure 2. (A) Post-modification of UIO-PBA&FDP and the procedure of HILIC enrichment for glycopeptides and analysis from biological Sample; (B-D) XRD patterns, FT-IR spectra and TEM image of as-synthesized UIO-PBA&FDP; (E) MALDI-TOF MS of peptide mixtures of 100 fmol/μL tryptic digests of IgG with enrichment by UIO-PBA&FDP for 3 cycles. The red stars represent glycopeptides; (F) Venn diagram showing the overlapping of unique glycosylated peptides; (G) The motif analysis of glycosylation sites identified from human serum after enrichment by UIO-PBA&FDP. (A-G) are reprinted with permission from Ref.^[96], Copyright © 2023 by Springer Nature. HILIC: Hydrophilic interaction chromatography; XRD: X-ray diffraction; FT-IR: Fourier transform infrared spectroscopy; TEM: transmission electron microscope; MALDI-TOF MS: matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; IgG: immunoglobulin G.