fig5

Figure 5. Analysis of sncRNA-loaded EV dosages in vitro. (A) Pie chart illustrating the percentage of studies that performed molecular target analysis assays, biological effect assays, or both in vitro; (B) Pie chart showing the distribution of EV dosages and measurement units used in molecular target analysis assays; (C) Pie chart illustrating the distribution of EV dosages and measurement units used in biological effect assays; (D) Graphical representation of doses based on protein quantification used in molecular target analysis assays; (E) Graphical representation of reported doses based on protein quantification used in biological effect assays; (F) Graphical representation of reported doses based on particle quantification used in biological effect assays. sncRNA: Small non-coding RNAs; EVs: extracellular vesicles; EV: extracellular vesicle.