fig1

Figure 1. Epigenetic regulation of gene expression in the heart. DNA methylation, histone modifications, and chromatin remodeling act together to control cardiac development and adaptation to stress. DNMT: DNA methyltransferase; 5mC: 5-methylcytosine; TET: ten-eleven translocation (dioxygenase) enzymes; HDACs: histone deacetylases; HDMs: histone demethylases; HATs: histone acetyltransferases; HMTs: histone methyltransferases; Me1: mono-methylation; HF: heart failure. Figure created in BioRender. Stephens, S. (2026) https://BioRender.com/n26cejf.