fig2

How photoenzymatic radical reactions are integrated into microbial biosynthesis

Figure 2. Scope of photoenzymatic radical transformations enabled by semi-integrated photobiosynthesis: (A) hydroamination, (B) hydrosulfonylation, and (C-E) hydroalkylation. Adapted with permission from[1], Copyright 2026, Springer Nature. ICD: Isocitrate dehydrogenase; GDH: glucose dehydrogenase; OYE3: ene-reductases (from Saccharomyces cerevisiae); OYE1: ene-reductases (from Saccharomyces pastorianus); GluER: ene-reductase (from Gluconobacter oxydans); PPEP: 4-(2-(piperidin-1-yl)ethyl)phenol; DIPB: 1,4-diphenylbutan-1-one; MPSB: 1-methyl-4-(phenethylsulfonyl)benzene; PPPy: 4-(3-phenylpropyl) pyridine; CPPB: 2-chloro-4-phenyl-1-(pyrrolidin-1-yl)butan-1-one.

Chemical Synthesis
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